Gideon Agus Nuswantoro
Founder & CEO
Founder of Orvana Health with 20+ years across marketing, consumer business, operations, and venture portfolio management.
Oral microbiome intelligence · Southeast Asia
Know your mouth.
Protect your future.
One saliva sample, read by AI, mapped to the bacteria that signal risk — for your mouth and the diseases it predicts. Built for Southeast Asia.
82
/100
Oral health index
Optimised microbiome with a moderate periodontal signal worth watching.
Microbiome readout — % relative abundance
Beneficial spp.80%
Neutral spp.60%
Harmful spp.20%
Risk signal
Caries riskLOW
Periodontal signalMODERATE
Inflammation indexSTABLE
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Recommendation. Floss daily and raise fiber intake to lower inflammation-associated species over the next cycle.
About us
Reading the mouth to read the body.
Orvana reads the oral microbiome — the bacterial community living in your mouth — and turns it into a risk readout you can act on. We started in Singapore in 2025 because Southeast Asia carries the disease burden and almost none of the early-warning infrastructure.
FoundedSingapore, 2025
IndustryHealthTech & AI
MissionPrevent disease, by data
VisionSEA's oral-health layer
Vision & Mission
Purpose-built for prevention.
By 2040, Orvana aims to become Asia's leading oral microbiome platform — grounded in clinical evidence and deployed at population scale.
"Use oral microbiome intelligence to help people predict, prevent, and personalize healthcare."
By 2040, Orvana aims to become
- Data Leadership The largest oral microbiome database in Asia.
- Consumer Trust A trusted preventive healthcare platform.
- Technology A leading AI-powered precision health company.
- Partnerships A key partner for healthcare providers, researchers, insurers, and life sciences organisations.
Research & clinical ecosystem
NUS Faculty of DentistryClinical partner
NUCOHSOral health centre
Duke-NUS Medical SchoolMedical school
Genome Institute of SingaporeGenomics
LifeStrands GenomicsGenomics partner
Our Ecosystem
An integrated platform.
Rather than selling a saliva test, build an integrated platform — connecting consumers, clinicians, enterprise, and research in one intelligence layer.
Consumer
- Saliva testing
- AI health reports
- Mobile app
- Family health management
- Nutrition guidance
- Personalised supplements
Healthcare
- Dentist dashboard
- Doctor dashboard
- Clinical decision support
- Telehealth integration
Enterprise
- Corporate wellness
- Insurance solutions
- Hospital analytics
- Research platform & AI APIs
Research
- Universities
- Pharmaceutical collaborations
- Biomarker discovery
- Clinical studies
The problem
Treated after it shows up.
Most chronic disease is caught late. 3.5 billion people live with oral disease, and the bacteria in the mouth — early signals for periodontal, cardiovascular and metabolic disease — are almost never read.
By the time symptoms appear, the cheapest window to intervene has closed. Orvana opens that window earlier, with a saliva sample and AI.
Caught late
Symptoms surface only after the cheapest window to act has already closed.
Siloed care
Dental and medical data rarely connect, so oral warning signs are missed.
Costly downstream
Emergency treatment and complications cost far more than early prevention.
Platform
From saliva to signal.
One integrated pipeline — non-invasive collection, AI reading microbial markers, and a report a clinician or consumer can act on the same day.
Test kit
Non-invasive saliva collection — the entry point to personalised microbiome intelligence.
AI engine
Proprietary models reading thousands of microbial markers in parallel.
Health intelligence
Risk scores and recommendations for individuals and clinicians.
Research
Microbiome data for academic and clinical-trial work.
Clinical pathways
Future diagnostics and therapeutics informed by the data.
Opportunity
A market opening early.
Preventive healthcare, AI diagnostics and the oral microbiome are converging — and Southeast Asia is under-served across all three.
Research
Built on evidence.
Peer-reviewed science, university collaborations, and a roadmap toward clinical-grade diagnostics — not claims ahead of the literature.
Output
Peer-reviewed publications
Contributing original work on the oral microbiome and its systemic links.
Network
University collaborations
Validation and expansion with leading research institutions.
Programmes
Innovation cohorts
Health-tech accelerators and government innovation programmes.
Roadmap
Toward clinical grade
Expanding biomarker databases and AI models toward diagnostic capability.
Partners
In conversation with.
Research, clinical and government institutions we're building alongside — not a logo wall of vendors.
NUS MedicineUniversity
Duke-NUSMedical school
A*STARResearch institute
SGHHospital
NTUUniversity
Enterprise SingaporeGovernment
NHICInnovation council
Leadership
Founder-led. Science-driven.
A team across company-building, technology, healthcare operations, diagnostics and regional growth.
Sagit Hariaji
Co-founder & CTO
Technology leader focused on enterprise systems, ERP, analytics, and bridging business needs with technical execution.
Carla Detera-Garganta, MD, DPPS
Co-founder & Head of Health
Healthcare and life-sciences leader across Singapore and the Philippines, with experience in clinical operations and partnerships.
Regional growth
Joel Balang
Marketing director, Malaysia
Entrepreneur and business builder across construction, hospitality, food & beverage, agriculture and real estate in Malaysia. At Orvana he leads market expansion through partnerships, brand growth and customer acquisition.
Adhi Ariyanto
Marketing director, Indonesia
Chief Marketing Officer at PT. Media Plus Galang Kreasi since 2009, shaping brand strategy and commercial partnerships across Greater Jakarta. At Orvana he leads marketing and go-to-market in Indonesia.
Advisory Board
Science at the table.
Clinical, genomics and research advisors from Singapore's leading institutions — providing scientific validation and strategic direction for Orvana's diagnostic platform.
Clinical Dentistry
NUS Faculty of Dentistry
National University of SingaporeOral microbiome research, clinical trial design, and evidence-based validation of diagnostic protocols.
Oral Health
NUCOHS
National University Centre for Oral Health SingaporePopulation-level oral health outcomes, patient pathway design, and preventive care integration.
Translational Medicine
Duke-NUS Medical School
Duke-National University of SingaporeSystemic disease linkages, AI in clinical decision-making, and interdisciplinary health research.
Genomics & Bioinformatics
Genome Institute of Singapore
A*STAR Research InstituteMicrobial genomics, bioinformatics pipelines, and biomarker discovery for oral microbiome profiling.
Genomics Technology
LifeStrands Genomics
SingaporeLaboratory operations, genomics technology partnerships, and end-to-end sequencing for clinical and consumer applications.
Contact
Let's build the future of oral health, together.
Investor, research partner, healthcare provider or government agency — tell us how you'd like to collaborate.