Evidence

What the literature says.

The studies Orvana's risk readouts build on. All peer-reviewed, each chosen because it shows the oral microbiome doing real predictive work — not because it sounds good in a deck.

Headline signalOral → systemic
9.5×
Odds ratio · esophageal SCC

Distinct oral microbial signatures carried a 9.5-fold odds ratio for esophageal squamous cell carcinoma — among the strongest statistical links in the field.

Int J Mol Sci · 202510.3390/ijms26199457 ↗
Selected studies

Four reads on the microbiome.

From cancer-risk prediction to saliva as a biomarker — the evidence base supporting risk stratification from an oral sample.

P-001Cancer risk · 2025
Cancer risk prediction
Int J Mol Sci · 2025
Key finding

Specific oral microbial signatures carried a 9.5-fold odds ratio for esophageal squamous cell carcinoma — one of the strongest statistical links in the literature.

Why it matters

Sets a precedent for microbiome-based risk prediction with statistical rigour.

Read study ↗
P-002Prevention · 2024
Prevention first
Microorganisms · 2024
Key finding

Probiotics and oral-hygiene interventions shift the oral microbiome and reduce downstream disease risk.

Why it matters

Supports Orvana's preventive positioning and gives users actionable levers.

Read study ↗
P-003Cardiometabolic · 2022
Cardiometabolic health
Front Immunol · 2022
Key finding

Changes in oral microbial communities track cardiometabolic risk factors and systemic inflammation.

Why it matters

Maps clear mechanistic links between oral dysbiosis and heart/metabolic disease risk.

Read study ↗
P-004Saliva · 2021
Saliva as biomarker
Diagnostics · 2021
Key finding

Salivary microbial profiling is a validated, non-invasive source for monitoring diabetes, cardiovascular and neurodegenerative conditions.

Why it matters

Justifies Orvana's at-home saliva collection model and consumer workflow.

Read study ↗

Evidence, then claims.

Every readout Orvana ships traces back to peer-reviewed work. We publish sources rather than asking you to take the science on trust — and we update this list as the evidence moves.

Discuss the research